Welcome!As a former graduate student in the Natarajan research group, we aimed to develop chemical inhibitors of protein-protein interactions (i-PPI). The eclectic research group, made up of chemists and biologists, used any experimental means necessary to solve problems of biomedical significance. Here, you will find details related to our previous efforts to build small molecule inhibitors (SMIs) to disrupt single nodes in the extraordinarily complex signaling network of the cell.
As a postdoc in the Diehl research group, we combined elements of chemical and systems biology to dissect the molecular-level mechanisms underlying specific neuronal degenerative diseases. Specifically, we exploited the biophysical approaches and modeling techniques developed by in the lab to determine the overall behavior of collective molecular motors and their relationship to specific motor neuron diseases. As a research scientist at Drugshoppe, I am working to develop a research program centered on developing small molecules to enable safer and more effective gene therapeutics. To that end, we are currently working on approaches to generalize the binding interactions of various nucleases and to understand the biophysics and structural dynamic that determine how they can be inhibited or activated. Our current work is focused on: 1) developing algorithmic models to predict various properties of potential therapeutics and 2) developing in vitro methodology to identify and characterize high-affinity inhibitors. Feel free to stay for awhile and browse around! |
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